Missouri, located in the Midwestern region of the United States, is a state known for its rich history, charming small towns, and vibrant cities. With its picturesque countryside, towering forests, and bustling urban centers, Missouri offers a unique blend of nature and culture. To help visitors and residents navigate this beautiful state, we have created a detailed map of Missouri with cities and highways.
This map highlights Missouri’s major cities, including Kansas City, St. Louis, Springfield, and Columbia, as well as its primary highways and roads. Whether you’re planning a road trip or simply want to explore Missouri’s distinctive landscape and culture, this map is an essential tool. So, grab your map and get ready to discover all that Missouri has to offer, from its historic landmarks to its charming small towns and everything in between.
Printable Missouri Map With Cities and Highways
Cities
Arnold
Arnold is a charming city located in Jefferson County, Missouri, United States, and a suburb of St. Louis. The city is known for its friendly locals, deep sense of cultural heritage, and stunning natural beauty. The population of Arnold was 20,858 at the 2020 United States Census, making it a relatively small city.
Despite its size, Arnold offers a range of attractions and amenities, from beautiful parks and nature reserves to historic landmarks and cultural institutions. Visitors can explore the city’s amazing blend of urban and rural landscapes, as well as its rich history and vibrant arts scene.
With its warm climate, welcoming community, and breathtaking scenery, Arnold is a must-visit destination for anyone traveling to Missouri who wants to experience the state’s heritage and natural beauty.
Belton
Belton is a picturesque city located in northwestern Cass County, Missouri, United States. The city is known for its small-town charm, friendly locals, and beautiful natural surroundings. The population of Belton was 23,116 at the 2010 census, making it a relatively small city.
Despite its size, Belton offers a range of attractions and amenities, from beautiful parks and nature reserves to historic landmarks and cultural institutions. Visitors can explore the city’s dazzling blend of urban and rural landscapes, as well as its history and its lively arts scene.
With its warm climate, welcoming community, and gorgeous scenery, Belton is a must-visit destination for anyone traveling to Missouri who wants to experience the state’s cultural heritage and natural beauty.
Blue Springs
Blue Springs is a vibrant city located in Jackson County, Missouri, United States. The city is known for its beautiful parks, top-notch schools, and friendly locals. Blue Springs is located just 19 miles (31 km) east of downtown Kansas City, making it a popular destination for visitors looking to explore the region’s many attractions and amenities.
As the 9th largest city in the Kansas City Metropolitan Area and the 10th largest city in the state of Missouri, Blue Springs offers a range of cultural institutions, historic landmarks, and natural attractions.
The population of Blue Springs was 58,604 at the 2020 census, making it a relatively large city in the state. With its warm weather, friendly community, and dramatic scenery, Blue Springs is an essential destination for anyone traveling to Missouri.
Cape Girardeau
Cape Girardeau, colloquially referred to as “Cape,” is a wonderful city located in Cape Girardeau and Scott Counties in the U.S. state of Missouri. The city is one of two principal cities of the Cape Girardeau-Jackson, MO-IL Metropolitan Statistical Area, which encompasses Alexander County, Illinois, Bollinger County, Missouri, and Cape Girardeau County, Missouri, and has a population of 97,517. At the 2020 census, the population of Cape Girardeau was 39,540.
The city is the economic center of Southeast Missouri and also the home of Southeast Missouri State University. Cape Girardeau is located approximately 100 miles (161 km) southeast of St. Louis and 150 miles (241 km) north of Memphis. The city is known for its rich cultural heritage, historic landmarks, and natural landscapes.
Visitors can explore the city’s many parks and nature reserves, as well as its absorbing arts scene and top-notch restaurants. With its warm climate, friendly locals, and breathtaking scenery, Cape Girardeau is a must-visit spot for anyone traveling to Missouri who wants to experience the state’s unique cultural heritage and natural beauty.
Carthage
Carthage is a charming city located in Jasper County, Missouri, United States. The city is known for its rich history, vibrant arts scene, and natural beauty. Carthage is the county seat of Jasper County and is nicknamed “America’s Maple Leaf City.”
The population of Carthage was 15,522 as of the 2020 census, making it a relatively small city. Despite its size, Carthage offers a range of hotspots and amenities, from beautiful parks and nature reserves to historic landmarks and institutions.
Visitors can explore the city’s attractive blend of urban and rural landscapes, as well as its rich heritage and immersive arts scene. With its pleasing climate, welcoming locals, and dazzling scenery, Carthage is a tremendous choice for anyone traveling to Missouri.
Chesterfield
Chesterfield is a beautiful city located in St. Louis County, Missouri, United States. The city is a western suburb of St. Louis and is known for its charming neighborhoods, top-notch schools, and pretty natural surroundings. As of the 2020 census, the population of Chesterfield was 49,999, making it the state’s fourteenth-largest city.
The broader valley of Chesterfield was originally referred to as “Gumbo Flats,” derived from its soil, which though very rich and silty, resembled gumbo when wet. Visitors to Chesterfield can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and top-notch restaurants.
With great weather, a thriving community spirit, and expansive scenery, Chesterfield is a satisfying option for anyone who wants to experience the state’s local culture, heritage, and prosperity.
Columbia
Columbia is a delightful city located in the U.S. state of Missouri. The city is the county seat of Boone County and home to the University of Missouri. Founded in 1821, Columbia is the principal city of the five-county Columbia metropolitan area. It is Missouri’s fourth most populous and fastest-growing city, with an estimated 128,555 residents in 2022.
Columbia has a reputation for progressive politics, persuasive journalism, and public art. The tripartite establishment of Stephens College, the University of Missouri, and Columbia College has made Columbia a center of learning. Education is now Columbia’s primary economic concern, with secondary interests in the healthcare, insurance, and technology sectors.
The city is also home to cultural institutions like the State Historical Society of Missouri, the Museum of Art and Archaeology, the annual True/False Film Festival, and the Roots N Blues Festival. The Missouri Tigers, the state’s only major college athletic program, play football at Faurot Field and basketball at Mizzou Arena as members of the Southeastern Conference.
The city rests upon the forested hills and rolling prairies of Mid-Missouri, near the Missouri River valley, where the Ozark Mountains begin to transform into plains and savanna. The modern populace is unusually diverse, with over 8% foreign-born. White and black people are the largest ethnicities, and people of Asian descent are the third-largest group.
Farmington
Farmington is a charming city located in St. Francois County, Missouri, United States. The city is situated about 75 miles (121 km) southwest of St. Louis in the Lead Belt region of Missouri. As of the 2020 census, the population of Farmington was 18,217, making it a relatively small city. Farmington is also the county seat of St. Francois County, which adds to its importance as a cultural and economic hub in the region.
The city was established in 1822 as Murphy’s Settlement, named for William Murphy of Kentucky, who first visited the site in 1798. When St. Francois County was organized, the town was briefly called St. Francois Court House and later renamed to Farmington.
Visitors to Farmington can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and top-notch restaurants. With its warm climate, friendly locals, and breathtaking scenery, Farmington is a must-visit destination for anyone traveling to Missouri who wants to experience the state’s unique cultural heritage and natural beauty.
Fulton
Fulton is a vibrant city located in Callaway County, Missouri, United States. The city is the largest in the county and serves as its county seat. Located about 22 miles (35 km) northeast of Jefferson City and the Missouri River and 20 miles (32 km) east of Columbia, Fulton is part of the Jefferson City, Missouri, Metropolitan Statistical Area.
The population of Fulton was 12,790 in the 2010 census, making it a relatively small city. However, the city is home to several prestigious institutions, including two universities, Westminster College and William Woods University, the Missouri School for the Deaf, the Fulton State Hospital, and the Fulton Reception and Diagnostic Center state prison.
Additionally, Missouri’s only nuclear power plant, the Callaway Plant, is located 13 miles southeast of Fulton. Visitors to Fulton can explore the city’s many parks and nature reserves, as well as its exciting arts scene, engrossing heritage and history, and top-notch restaurants.
Hannibal
Hannibal is a charming city situated along the Mississippi River in Marion and Ralls counties in the U.S. state of Missouri. According to the 2020 U.S. Census, the population of Hannibal was 17,312, making it the largest city in Marion County. The bulk of the city is in Marion County, with a tiny sliver in the south extending into Ralls County.
Hannibal was developed for river traffic, but today the city is tied to vehicle traffic, intersected by Interstate 72 and U.S. Routes 24, 36, and 61. The city is located across the river from East Hannibal, Illinois. Hannibal is approximately 100 miles (160 km) northwest of St. Louis, 210 miles (340 km) east-northeast of Kansas City, and 194 miles (312 km) miles east of Saint Joseph. Hannibal is not the county seat, but it has one of two county courthouses.
The city is also the principal city of the Hannibal, Missouri micropolitan area, which consists of both Marion and Ralls counties. Visitors to Hannibal can explore the city’s many parks and nature reserves, as well as its exciting artistic community and top-notch culinary scene.
Independence
Independence is a vibrant city located in Jackson County, Missouri, United States. The city is the fifth-largest in Missouri and serves as the county seat of Jackson County. Independence is also a satellite city of Kansas City, Missouri, and is the largest suburb on the Missouri side of the Kansas City metropolitan area.
In 2020, the city had a total population of 123,011, making it a relatively large city. Independence is known as the “Queen City of the Trails” because it was a point of departure for the California, Oregon, and Santa Fe Trails.
The city is also the hometown of U.S. President Harry S. Truman, with the Truman Presidential Library and Museum, and the gravesites of Truman and First Lady Bess Truman. Additionally, Independence is sacred to the Latter Day Saint movement, as the home of Joseph Smith’s 1831 Temple Lot, and the headquarters of several Mormon denominations.
Visitors to Independence can explore parks and nature reserves, an artistic community, and delicious local food. Additionally, the gorgeous weather, welcoming locals, and breathtaking scenery make Independence an exceptional choice for both residents and tourists.
Jackson
Jackson is a beautiful city located in Cape Girardeau County, Missouri, United States. The city serves as the county seat of Cape Girardeau County and is a principal city of the Cape Girardeau–Jackson, MO-IL Metropolitan Statistical Area. The population of Jackson was 15,481 at the 2020 census, making it a relatively small city.
Visitors to Jackson can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and marvelous restaurants. With its warm climate, friendly locals, and breathtaking scenery, Jackson is a must-visit destination for anyone traveling to Missouri who wants to experience the state’s distinctive cultural heritage and natural beauty.
Jefferson City
Jefferson City, informally known as Jeff City, is the capital of the U.S. state of Missouri. The city had a population of 43,228 at the 2020 census, ranking as the 15th most populous city in the state. Jefferson City is also the county seat of Cole County and the principal city of the Jefferson City Metropolitan Statistical Area, the second-most-populous metropolitan area in Mid-Missouri and the fifth-largest in the state.
Most of the city is in Cole County, with a small northern section extending into Callaway County. Jefferson City is named for Thomas Jefferson, the third President of the United States. The city is located on the northern edge of the Ozark Plateau on the southern side of the Missouri River in a region known as Mid-Missouri, roughly midway between the state’s two large urban areas of Kansas City and St. Louis.
Jefferson City is dominated by the domed Capitol, which rises from a bluff overlooking the Missouri River to the north. The city is also home to Lincoln University, a public historically black land-grant university founded in 1866 by the 62nd Regiment of U.S. Colored Troops with support from the 65th Regiment of U.S. Colored Troops.
Visitors to Jefferson City can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and top-notch restaurants. With its warm climate, friendly locals, and breathtaking scenery, Jefferson City is an essential location for anyone traveling to Missouri.
Joplin
Joplin is a vibrant city located in Jasper and Newton counties in the southwestern corner of the U.S. state of Missouri. The bulk of the city is in Jasper County, while the southern portion is in Newton County. With a population of 51,762 as of the 2020 census, Joplin is the 13th most populous city in the state. The city covers an area of 35.69 square miles (92.41 km2) on the outer edge of the Ozark Mountains.
Joplin is the main hub of the three-county Joplin-Miami, Missouri-Oklahoma Metro area, which is home to 210,077 people, making it the 5th largest metropolitan area in Missouri. Unfortunately, in May 2011, a violent EF5 tornado hit Joplin, killing more than 150 people and destroying one-third of the city. Despite this tragedy, Joplin has made a remarkable recovery and has become a symbol of resilience and strength.
Visitors to Joplin can enjoy parks and nature reserves, a rich cultural scene, amazing food, beautiful natural surroundings, and a great sense of community spirit. Joplin’s exciting mix of culture, heritage, and friendliness marks it out as an exceptional destination.
Kansas City
Kansas City, Missouri, also known as KC or KCMO, is the largest city in Missouri by population and area. As of the 2020 census, the city had a population of 508,090, making it the 37th most populous city in the United States. Kansas City is the urban central city of the Kansas City metropolitan area, which straddles the Missouri–Kansas state line and has a population of 2,392,035.
Most of the city lies within Jackson County, with portions spilling into Clay, Cass, and Platte counties. Kansas City was founded in the 1830s as a port on the Missouri River at its confluence with the Kansas River from the west. The city encompasses about 319.03 square miles (826.3 km2), making it the 25th largest city by total area in the United States.
The city is composed of several neighborhoods, including the River Market District in the north, the 18th and Vine District in the east, and the Country Club Plaza in the south. Kansas City is known for its celebrated cultural traditions, including Kansas City jazz, theater, the Chiefs and Royals sports franchises, and famous cuisine based on Kansas City–style barbecue, strip steak, and craft breweries.
Visitors to Kansas City can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and top-notch restaurants. With its warm climate, friendly locals, and breathtaking scenery, Kansas City is a must-visit destination for anyone traveling to Missouri who wants to experience the state’s wonderful cultural heritage and natural beauty.
Kirksville
Kirksville is a charming city located in Adair County, Missouri. The city serves as the county seat and is the most populous city in Adair County. Located in Benton Township, Kirksville had a population of 17,530 at the 2020 census.
Kirksville is home to two prestigious colleges: Truman State University and A.T. Still University. Truman State University is a public liberal arts and sciences university and is known for its highly selective admissions process and rigorous academic programs. A.T. Still University is a private health sciences university and is known for its osteopathic medicine program.
Visitors to Kirksville can explore local parks and nature reserves, savor the warm weather and friendly locals, and experience the state’s unique heritage and atmosphere.
Kirkwood
Kirkwood is a picturesque city located in St. Louis County, Missouri. The city is an inner-ring western suburb of St. Louis and was founded in 1853. Kirkwood is named after James P. Kirkwood, builder of the Pacific Railroad through that city. As of the 2010 census, the city’s population was 27,540.
Kirkwood was the first planned suburb located west of the Mississippi River, making it a historically significant city. Visitors to Kirkwood can explore the city’s many parks and nature reserves, as well as its amazing arts scene and superb food.
Lebanon
Lebanon is a charming city located in Laclede County, Missouri. The city serves as the county seat and is home to a population of 14,474 people as of the 2010 census. Lebanon is known for its rich history and culture, with many historic sites and landmarks throughout the city.
As the county seat of Laclede County, Lebanon is an important hub for government and commerce in the region. The city is also home to the Lebanon Micropolitan Statistical Area, which encompasses Laclede County. Visitors to Lebanon can explore the city’s natural beauty, as well as its brilliant cultural and culinary hotspots.
Lees Summit
Lee’s Summit is a vibrant city located in the U.S. state of Missouri and is a sought-after suburb in the Kansas City metropolitan area. The city straddles Jackson and Cass counties and is home to a population of 101,108 people as of the 2020 census, making it the sixth-largest city in both Missouri and the Kansas City metropolitan area.
Lee’s Summit is known for its beautiful parks, marvelous schools, and immersive community events. With its warm climate, friendly locals, and breathtaking scenery, Lee’s Summit is a must-visit destination for anyone traveling to Missouri who wants to experience the state’s unique cultural heritage and natural beauty.
Liberty
Liberty is a charming city located in Clay County, Missouri, and is a sought-after suburb of Kansas City. The city serves as the county seat and is home to a population of 30,167 people as of the 2020 United States Census. Liberty is known for its deep history and culture, with many historic sites and landmarks throughout the city.
The city is also home to William Jewell College, a private liberal arts college known for its rigorous academic programs and highly selective admissions process. Visitors to Liberty will be charmed by the city’s parks and nature reserves, as well as its dazzling arts community and amazing restaurants.
Marshall
Marshall is a charming city located in Saline County, Missouri. The city serves as the county seat and is home to a population of 13,065 people as of the 2010 census. Marshall is known for its rich heritage and culture, with many historic sites and landmarks throughout the city.
As the county seat of Saline County, Marshall is an important hub for government and commerce in the region. The city is also home to the Marshall Micropolitan Statistical Area, which encompasses Saline County.
Marshall is also home to Missouri Valley College, a private liberal arts college known for its strong academic programs and vibrant campus life. With its warm climate, friendly locals, and breathtaking scenery, Marshall is an unmissable location in Missouri.
Maryville
Maryville is a charming city located in the “Missouri Point” region and serves as the county seat of Nodaway County, Missouri. As of the 2020 census, the city had a population of 10,633 people. Maryville is known for its rich heritage and culture, with many historic sites and landmarks throughout the city.
The city is also home to Northwest Missouri State University, a public university known for its strong academic programs and vibrant campus life, as well as Northwest Technical School. Maryville was the second-largest city in the 1836 Platte Purchase, which expanded Missouri’s borders into former Indian Territory in northwest Missouri, with St. Joseph being the largest.
With an abundance of culture, history, and community spirit, and a bustling economy and culinary scene, Maryville is a wonderful spot to put down roots and settle, or just to visit and explore.
Mexico
Mexico is a charming city located in Audrain County, Missouri, and serves as the county seat. Formerly known as New Mexico, the city is home to the Missouri Military Academy, a prestigious private military school known for its rigorous academic programs and strong emphasis on leadership and character development.
Mexico is also known for hosting the annual Miss Missouri Pageant, a popular event that attracts visitors from all over the state. As of the 2020 census, the city had a population of 11,469 people. The Mexico Micropolitan Statistical Area consists of Audrain County and is a part of the larger Columbia, Missouri metropolitan area.
Visitors to Mexico will experience the warmth of the friendly locals, along with the beauty of the natural surroundings. They’ll also be charmed by the culture and history of this wonderful location.
Moberly
Moberly is a charming city located in Randolph County, Missouri, and is part of the larger Columbia, Missouri metropolitan area. As of the 2010 census, the city had a population of 13,974 people. Moberly is known for its rich history and culture, with many historic sites and landmarks throughout the city.
Visitors to Moberly can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and top-notch restaurants. Moberly is also home to a variety of festivals and events throughout the year, including the Moberly Five and Drive, an annual car show that attracts visitors from all over the state.
O’Fallon
O’Fallon is a thriving city located in St. Charles County, Missouri, and is part of the St. Louis metropolitan statistical area. The city is situated along Interstates 64 and 70 between Lake St. Louis and St. Peters. As of the 2020 census, O’Fallon had a population of 91,316 people, making it the largest suburb of St. Louis and the largest municipality in St. Charles County, as well as the seventh-largest in Missouri.
O’Fallon is known for its excellent schools, up-to-date amenities, and vibrant community events. The city is also home to a variety of parks and nature reserves, as well as a thriving arts scene and a wide range of restaurants and shops.
O’Fallon is also unique in that it shares its name with a city in St. Clair County, Illinois, which is also part of the St. Louis region. The two cities are one of the few pairs of same-named municipalities to be part of the same metro area.
Poplar Bluff
Poplar Bluff is a charming city located in Butler County in Southeast Missouri, United States. It serves as the county seat and is known as “The Gateway to the Ozarks” among other names. As of the 2020 census, the city had a population of 16,225 people. Poplar Bluff is known for its rich history and culture, with many historic sites and landmarks throughout the city.
The city is also home to the Poplar Bluff Micropolitan Statistical Area, which encompasses all of Butler County. Poplar Bluff is at the crossroads of U.S. Route 60 and U.S. Route 67, making it an important hub for transportation and commerce in the region. With its warm weather, friendly people, and gorgeous scenery, Poplar Bluff is an unmissable destination for anyone traveling to Missouri.
Rolla
Rolla is a vibrant city located in Phelps County, Missouri, and serves as the county seat. As of the 2020 United States Census, the city had a population of 19,943 people. Rolla is known for its rich history and culture, with many historic sites and landmarks throughout the city. The city is approximately midway between St. Louis and Springfield along I-44, making it an important hub for transportation and commerce in the region.
Rolla is also home to the Missouri University of Science and Technology, a prestigious public research university known for its many engineering and computer science departments. The headquarters of the Mark Twain National Forest is also located in Rolla, making it an important center for conservation and outdoor recreation in the region.
The city is also within the Ozark Highlands American Viticultural Area, with vineyards first established by Italian immigrants to the area. Visitors to Rolla can explore the city’s many parks and nature reserves, as well as its vibrant arts scene and top-notch restaurants.
Saint Charles
Saint Charles, commonly abbreviated as St. Charles, is a historic city located in St. Charles County, Missouri, and serves as the county seat. As of the 2020 census, the city had a population of 70,493 people, making it the ninth-largest city in Missouri. Situated on the Missouri River, St. Charles is a northwestern suburb of St. Louis.
The city was founded circa 1769 as Les Petites Côtes, or “The Little Hills” in French, by Louis Blanchette, a French-Canadian fur trader. St. Charles is the third-oldest city in Missouri and played a significant role as a river port in the United States’ westward expansion, including trade with Native American tribes on the upper Missouri River.
It was also the starting point of the Boone’s Lick Road to the Boonslick. St. Charles was settled primarily by French-speaking colonists from Canada in its early days. In 1804, the Lewis and Clark Expedition considered this settlement the last “civilized” stop before they headed upriver to explore the western territory that the United States acquired from France in the Louisiana Purchase.
The city served as the first Missouri capital from 1821 to 1826 and is the site of the Saint Rose Philippine Duchesne shrine. The pleasing climate, friendly community, and beautiful scenery make St. Charles a great choice for anyone traveling to Missouri.
Saint Joseph
Saint Joseph is a vibrant city located in Andrew and Buchanan counties and serves as the county seat of Buchanan County, Missouri, United States. The city is located on the Missouri River and is the principal city of the St. Joseph Metropolitan Statistical Area, which includes Buchanan, Andrew, and DeKalb counties in Missouri and Doniphan County, Kansas.
As of the 2020 census, St. Joseph had a total population of 72,473 people, making it the eighth-largest city in the state and the third-largest in Northwest Missouri. St. Joseph is located roughly thirty miles north of the Kansas City, Missouri, city limits and approximately 125 miles (201 km) south of Omaha, Nebraska. The city was named after the town’s founder Joseph Robidoux and the biblical Saint Joseph.
St. Joseph is home to Missouri Western State University and is the birthplace of rapper and songwriter Eminem, who grew up in and has made his career in Detroit, Michigan. In the nineteenth century, it was the death place of American outlaw Jesse James. St. Joseph was also the starting point of the Pony Express, which served the West.
Visitors to St. Joseph will be delighted by its many historic sites, landmarks, and restaurants. With its warm weather and friendly locals, St. Joseph is a must-visit spot for anyone traveling to Missouri.
Saint Louis
Saint Louis, commonly abbreviated as St. Louis, is the second-largest city in Missouri, United States. It is located near the confluence of the Mississippi and Missouri rivers. In 2020, the city proper had a population of 301,578 people, while its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million people, making it the largest metropolitan area in Missouri and the second largest in Illinois.
Before European settlement, the area had been occupied for thousands of years by various Native American cultures. St. Louis was founded on February 14, 1764, by French fur traders Gilbert Antoine de St. Maxent, Pierre Laclède, and Auguste Chouteau, all from New Orleans. It quickly became the regional center of the French Illinois Country and developed as a major port on the Mississippi River in the 19th century.
St. Louis is a global city with a diverse economy and is home to eight Fortune 500 companies, major research universities, and federal agencies. It also has four professional sports teams and many notable attractions, including the Gateway Arch, the St. Louis Zoo, and the Missouri Botanical Garden.
Sedalia
Sedalia is a charming city located approximately 30 miles (50 kilometers) south of the Missouri River and serves as the county seat of Pettis County, Missouri, United States. It is the principal city of the Sedalia Micropolitan Statistical Area. As of the 2010 census, the city had a total population of 21,387 people.
Sedalia is known for its many cultural events, including the Missouri State Fair and the Scott Joplin Ragtime Festival, which celebrates the life and work of the famous ragtime composer who lived in Sedalia in the early 1900s.
The city is also a popular destination for outdoor enthusiasts, with many parks, nature reserves, and hiking trails in the surrounding area. U.S. Routes 50 and 65 intersect in the city, making it an important hub for transportation and commerce in the region. Visitors to Sedalia can explore the city’s many historic sites and landmarks, as well as its vibrant arts scene and top-notch restaurants.
Sikeston
Sikeston is a charming city located both in southern Scott County and northern New Madrid County, in the state of Missouri, United States. It is situated just north of the “Missouri Bootheel,” although many locals consider Sikeston a part of it. The city is named after John Sikes, who founded it in 1860.
By way of Interstate 55, Interstate 57, and U.S. Route 60, Sikeston is close to the halfway point between St. Louis and Memphis, Tennessee, and is three hours from Nashville. Sikeston is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41,143 people.
As of the 2020 census, the city population was 16,291 people, making it the fourth-most populous city in Missouri’s 8th Congressional district behind Cape Girardeau, Rolla, and Farmington, and just ahead of Poplar Bluff which has had a similar population as Sikeston over the last few decades.
Before the 2010 census, it had been the second-most populous city in the congressional district. Visitors to Sikeston will be delighted by its rich combination of culture, gorgeous weather, natural scenery, and history.
Springfield
Springfield is the third-largest city in the U.S. state of Missouri and the county seat of Greene County. The city’s population was 169,176 at the 2020 census and it is the principal city of the Springfield metropolitan area, which had an estimated population of 481,483 in 2021. The area includes the counties of Christian, Dallas, Greene, Polk, and Webster and is the second-fastest-growing metropolitan area in the state of Missouri.
Springfield is known as the “Queen City of the Ozarks” as well as “The 417” after the area code for the city. It is also known as the “Birthplace of Route 66” and is home to several universities and colleges, including Missouri State University, Drury University, and Evangel University.
The city is an important center of education and medical care, with two of the largest hospitals in the area, CoxHealth and Mercy, employing over 20,000 people combined and being the largest employers in the region. Springfield has been called the “Buckle of the Bible Belt” due to its association with evangelical Christianity and has been growing more diverse over the decades.
The city is known for its outdoor recreation activities, with nearly 100 city parks and 140 miles (230 km) of outdoor bike trails. Springfield is also home to Bass Pro Shops, the number one tourist attraction in the state of Missouri, and the adjoining Wonders of Wildlife Museum & Aquarium, the world’s largest wildlife attraction.
Washington
Washington is a picturesque city located on the south banks of the Missouri River, just 50 miles west of St. Louis, Missouri. It is the largest city in Franklin County, Missouri, United States. The estimated population in July 2021 was 14,916, which is an increase of 7% since the 2010 census.
The city is known as the corncob pipe capital of the world, with Missouri Meerschaum located on the riverfront. Visitors to Washington can tour the Missouri Meerschaum factory and learn about the history of corncob pipes in the United States. The city is also home to many other attractions, including the historic downtown district, which features a variety of shops, restaurants, and galleries.
Outdoor enthusiasts will enjoy exploring the many parks and nature reserves in the area, including the Katy Trail State Park, which is a popular destination for hiking, biking, and horseback riding. With its warm climate, friendly locals, and breathtaking scenery, Washington is an unmissable location for anyone traveling to Missouri who wants to experience the state’s cultural heritage and natural beauty.
Highways
Route 24
Route 24 in Missouri is a major highway that serves many cities and towns in the state. It passes through Kansas City, Independence, Buckner, Lexington, Waverly, Carrollton, Keytesville, Moberly, Madison, Monroe City, Palmyra, and West Quincy. The highway runs concurrently with US 65 between Waverly and Carrollton, passing over the Missouri River via the Waverly Bridge when concurrent.
After becoming a two-lane road, it is then concurrent with Route 5 in Keytesville and passes by the city of Huntsville before turning into a four-lane highway and crossing US 63 at Moberly. It is finally concurrent with US 36 east of Monroe City and with US 61 from south of Palmyra to West Quincy.
The segment shared with US 61 is part of the Avenue of the Saints. Along the route within Independence is the Harry S. Truman Presidential Library and Museum, a popular tourist attraction for visitors to the area.
Route 36
Route 36 in Missouri is an important expressway that connects Kansas to Illinois. It is also part of the principal route between Kansas City and Chicago, known as the Chicago-Kansas City Expressway. The highway features many freeway sections and is an essential transportation link for travelers in the region.
All of US 36 in Missouri is named the V.F.W. Memorial Highway, a tribute to the brave men and women who have served in the United States Armed Forces. As travelers make their way along this historic highway, they can enjoy stunning views of the Missouri countryside and explore the many small towns and communities that dot the landscape.
Whether you are traveling for business or pleasure, Route 36 in Missouri is a must-drive for anyone looking to experience the distinctive heritage and natural beauty of the state.
Route 50
Route 50 in Missouri is a key east-west highway that spans the state. It is a brilliant transportation link for travelers, connecting many of Missouri’s largest cities and towns. The highway is known for its scenic views and passes through some of the state’s most beautiful landscapes.
In the state capital of Jefferson City, Route 50 is known as the Rex M. Whitton Expressway, named in honor of a former mayor of the city. Visitors to the area can explore the many historic sites and landmarks in the city, including the Missouri State Capitol and the Governor’s Mansion.
Whether you are driving for business or pleasure, Route 50 in Missouri is a great choice for anyone looking to explore the heritage and beauty of the state.
Route 54
Route 54 in Missouri is a principal east-west highway that runs from the southwest portion of the state to the northeast. It is a critical transportation link for travelers, passing through many rural towns and communities along the way.
The highway is the primary access road to Pomme de Terre Lake and Lake of the Ozarks, two of Missouri’s most popular tourist destinations. Along the route, travelers can explore the many historic sites and landmarks in the area, including Ha Ha Tonka State Park and the Missouri State Capitol in Jefferson City.
US 54 is also part of the National Highway System, a system of highways important to the nation’s defense, economy, and mobility.
Route 59
Route 59 in Missouri is a highway in southwest Missouri that runs from Interstate 44/Interstate 49/U.S. Route 71 at Fidelity to the Arkansas state line, where it continues as Highway 59. The highway was created to replace a large section of U.S. Route 71 and Alternate US 71 in sections.
The first section was designated in 1960 between Lanagan and the Arkansas state line when US 71 was moved down the former Route 88. In the 1990s, US 71 was moved and upgraded to interstate standards from Neosho to Lanagan, and Route 59 was extended north to Neosho. When US 71 was moved east of Joplin in the late 1990s, Alternate US 71 was deleted, and Route 59 was extended north to replace that highway.
The highway was numbered after Arkansas Highway 59. Travelers along this route can enjoy scenic views of the Missouri countryside and explore the many small towns and communities that dot the landscape.
Route 60
Route 60 in Missouri is a main east-west highway that runs through the southern part of the state, from the Oklahoma border to the Illinois border. As part of the United States Numbered Highway System, US 60 connects Brenda, Arizona, all the way to Virginia Beach, Virginia.
In Missouri, the highway is a critical transportation link for travelers, passing through many small towns and communities along the way. The route is known for its scenic views of the Missouri countryside and is a popular destination for outdoor enthusiasts looking to explore the state’s natural beauty.
Route 61
Route 61 in Missouri is a significant highway that runs through the state, connecting many of its largest cities and towns. The highway is divided from the Tennessee state line to U.S. 82 in Leland and is mostly four-lane with only short sections through Port Gibson being two-lane.
The road is also known as the Blues Highway because it runs through the Mississippi Delta country, which was an important source of blues music. Many musicians have referenced Highway 61 in their music, including Bob Dylan and Johnny Cash. The former junction of US 61 and U.S. 49 in Clarksdale is famous as the crossroads where Robert Johnson supposedly sold his soul to the Devil in exchange for mastery of the blues.
Route 63
Route 63 in Missouri is a key north-south highway that runs through the state, connecting the Arkansas state line near Thayer to the Iowa state line near Lancaster. As part of the United States Numbered Highway System, US 63 is an essential transportation link for travelers, passing through many small towns and communities along the way.
The route is known for its scenic views of the Missouri countryside and is a popular destination for outdoor enthusiasts looking to explore the state’s natural beauty.
Route 65
Route 65 in Missouri is a chief north-south U.S. highway that runs through the state, connecting many of its largest cities and towns. As part of the United States Numbered Highway System, US 65 enters Missouri from Arkansas, just south of Branson, and exits the state into Iowa near South Lineville.
The highway is an essential transportation link for travelers, passing through many small towns and communities along the way. Whether you are driving for business or pleasure, Route 65 in Missouri is a must-drive for anyone looking to experience the amazing cultural heritage and natural landscapes of the state.
Route 67
Route 67 in Missouri is a significant highway that runs through the state, connecting many of its largest cities and towns. Going from south to north, US 67 enters Missouri at the Arkansas state line and intersects with US 160 about 10 miles north of the state line. The highway bypasses Poplar Bluff to the west on a freeway-grade highway and then joins US 60 at the northwest corner of Poplar Bluff.
Both 60 and 67 then follow a four-lane route to an interchange about 6 miles northwest of Poplar Bluff, where US 60 heads west toward Springfield while US 67 heads north to St. Louis. The highway passes through many small towns and communities along the way, including Fredericktown, Farmington, Park Hills, Desloge, and Bonne Terre.
US 67 then crosses Interstate 55 and enters Festus and Crystal City, where it picks up US 61. Whether you are driving for business or just to see the sights, Route 67 in Missouri is a great option for anyone looking to experience the heritage and natural beauty of the state.
Route 69
Route 69 in Missouri is a key highway that runs through the state, connecting many of its largest cities and towns. US-69 enters Riverside, merges with I-635, then almost immediately exits and merges with MO-9, heading east.
The highway passes through many small towns and communities along the way, including Northmoor, Gladstone, Claycomo, Pleasant Valley, and parts of Kansas City proper before merging with I-35 for a second time, near Liberty. US-69 stays merged with I-35 for 7 miles before it exits. After exiting the highway, US-69 immediately merges with MO-33 and heads northeast.
The highway stays somewhat parallel to I-35 as it heads through Missouri, sometimes passing under it. US-69 merges with MO-6 west of Altamont, and the highways turn north, with MO-6 splitting from US-69 and heading west while US-69 continues heading north.
The highway merges with US-136 southwest of Bethany and heads east into the town. Whether you are driving for business or pleasure, Route 69 in Missouri is a wonderful way to experience the local cultural heritage and beauty.
Route 71
Route 71 in Missouri is a significant north-south U.S. highway that runs through the state, connecting many of its largest cities and towns. As part of the United States Numbered Highway System, US 71 enters Missouri from Arkansas in the town of Jane and serves the cities of Joplin, Kansas City, and St. Joseph.
The highway is a vital transportation link for travelers, passing through many small towns and communities along the way. At noon on December 12, 2012, the section of US 71 between Pineville, Missouri, and I-435 in south Kansas City was also designated as a northern extension of Interstate 49 (I-49), further increasing the highway’s importance to the state’s transportation infrastructure.
Route 136
Route 136 in Missouri is a significant highway that runs through the state, connecting many of its largest cities and towns. As part of the United States Numbered Highway System, US 136 enters Missouri on the west just east of Brownville, Nebraska, over the Missouri River, and leaves the state at Alexandria on the east, running concurrently with US 61.
During its journey, it enters every county seat in the nine counties it traverses. The distance across Missouri is approximately 240 miles, and US 136 is two lanes over its entire course through the state.
Route 159
Route 159 in Missouri is a short but significant highway that runs through the state, connecting the towns of Big Lake, Fortescue, and New Point. As part of the United States Numbered Highway System, US 159 enters Missouri by crossing the Missouri River near the Rulo bridge south of Big Lake, Missouri.
The highway crosses Interstate 29 near Fortescue, Missouri, before ending at US-59 near New Point. Despite its short length, Route 159 is an essential transportation link for travelers in the area, passing through many small towns and communities along the way. This makes it an essential choice when exploring the cultural heritage and natural beauty of the state.
Route 160
Route 160 in Missouri is a highway that runs through the state, connecting many of its largest cities and towns. As part of the United States Numbered Highway System, US 160 enters Missouri west of Mindenmines and intersects with Interstate 49/U.S. Route 71 at Lamar.
The highway goes southeast towards Springfield, where it intersects with Interstate 44 and U.S. Route 60, with which it has a short concurrency. US 160 then goes south out of Springfield into Nixa as Massey Boulevard then turns east and intersects with U.S. Route 65 north of Branson.
The highway continues east to West Plains, where it intersects with U.S. Route 63, before ending southwest of Poplar Bluff at an intersection with U.S. Route 67 (Future Interstate 57). In Willard, US 160 runs on a bypass along the western and southern edge of town, with the old alignment through Willard now designated as U.S. Route 160 Business.
Route 169
Route 169 in Missouri is a significant highway that runs through the state, connecting many of its largest cities and towns. As part of the United States Numbered Highway System, US 169 is a U.S. Highway that travels from Tulsa, Oklahoma, to Virginia, Minnesota. In the state of Missouri, US 169 enters the state from Kansas overlapped with I-70 / US 24 / US 40 at Kansas City.
The highway passes through many small towns and communities along the way, including Smithville, Gower, and Stanberry. US 169 then exits the state into Iowa north of Irena. Whether you are driving for business or pleasure, Route 169 in Missouri is a must-drive for anyone looking to experience the unique cultural heritage and natural beauty of the state.
Interstates
Interstate 29
Interstate 29 (I-29) in Missouri is a significant highway that runs through the state, connecting many of its largest cities and towns. As part of the Interstate Highway System, I-29 is a north-south interstate that begins in Missouri and travels through the Kansas City and St. Joseph metropolitan areas before exiting the state and entering Iowa.
Almost all of I-29 in Missouri lies in an area called the Platte Purchase, which was not originally part of Missouri when the state entered the Union in 1821. The highway is an essential transportation link for travelers in the area, passing through many small towns and communities along the way.
Interstate 35
Interstate 35 (I-35) in Missouri is a chief highway that runs through the state, connecting many of its largest cities and towns. As part of the Interstate Highway System, I-35 stretches from Laredo, Texas, in the south to Duluth in the north. The portion of I-35 through Missouri travels nearly 115 miles from just south of Kansas City, through the Downtown Loop, and across the Missouri River before leaving the downtown area.
The highway passes through many small towns and communities along the way, including Kearney, Cameron, and Bethany. North of Kansas City, I-35 travels north-northeast toward the Iowa state line near Eagleville, paralleling U.S. Route 69 (US 69). This makes it a wonderful way to experience the culture and beauty of the state.
Interstate 55
Interstate 55 (I-55) in Missouri is a key highway that runs through the state, connecting many of its largest cities and towns. As part of the Interstate Highway System, I-55 runs from the Arkansas state line to the Poplar Street Bridge over the Mississippi River in St. Louis.
The highway passes through many small towns and communities along the way, including Cape Girardeau, Perryville, and Festus. I-55 is an essential transportation link for travelers in the area, passing through several major metropolitan areas such as St. Louis and its suburbs.
Interstate 57
Interstate 57 (I-57) in Missouri is a vital highway that runs through the state, connecting many of its largest cities and towns. In the state of Missouri, I-57 runs northbound from Sikeston to the Cairo I-57 Bridge over the Mississippi River north of Cairo, Illinois. After ending southbound at I-55, the highway continues as U.S. Route 60 (US 60), which meets US 67 at Poplar Bluff.
From there, US 67 goes south to Little Rock, Arkansas. From the start of I-57 northbound, the US 60 concurrency goes about 12 miles. Whether you are driving for business or pleasure, Interstate 57 in Missouri is a must-drive for anyone looking to experience the unique cultural heritage and natural beauty of the state.
Interstate 44
Interstate 44 (I-44) in Missouri is an important highway that runs through the state, connecting many of its largest cities and towns. As part of the Interstate Highway System, I-44 runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles in the state, making it the longest Interstate Highway in Missouri.
The highway passes through many small towns and communities along the way, including Rolla, Lebanon, and Springfield. I-44 is an essential transportation link for travelers in the area, passing through several major metropolitan areas such as St. Louis and its suburbs. It is a perfect choice for anyone looking to explore the local culture and natural landscapes.
Interstate 70
Interstate 70 (I-70) in Missouri is a key highway that runs through the state, connecting many of its largest cities and towns. As part of the Interstate Highway System, I-70 is generally parallel to the Missouri River. This section of the transcontinental Interstate begins at the Kansas state line on the Intercity Viaduct, running concurrently with US Route 24 (US 24), US 40, and US 169.
The highway passes through many small towns and communities along the way, including Columbia, Kingdom City, and Wentzville. The east end of I-70 is on the Stan Musial Veterans Memorial Bridge in St. Louis, which crosses the Mississippi River into Illinois. I-70 is an essential transportation link for people in the area, passing through several major metropolitan areas such as Kansas City and St. Louis and its suburbs. It enables travelers to explore the heritage and beauty of the state with comfort and ease.
