Stretching an impressive 943 miles through Illinois, Indiana, and Ohio, the Ohio River Scenic Byway traces one of America’s most storied waterways from Cairo to the Pennsylvania border near East Liverpool. This National Scenic Byway follows the meandering curves of the Ohio River, revealing a tapestry of rolling hills, fertile bottomlands, and charming river towns that defined early American expansion westward.

Travelers will discover historic riverfront communities where steamboat heritage comes alive, from the antebellum architecture of Madison, Indiana, to the German-influenced streets of Cincinnati. Watch barges glide past towering limestone bluffs, explore underground railroad history, and visit riverside parks perfect for picnicking with sweeping water views. Highlights include the confluence of the Ohio and Mississippi Rivers at Cairo, the stunning overlooks near Hanover, Indiana, and the pottery heritage of East Liverpool.

The byway rewards those who linger—plan five to seven days to fully appreciate its offerings, though weekend segments work beautifully. Late spring brings dogwood blooms and migrating birds, while autumn transforms the river valley into a corridor of gold and crimson. Summer offers festivals and outdoor recreation, and winter reveals the stark beauty of bare bluffs against steely waters.

This is a journey through America’s heartland at its most authentic.

Explore Nearby

• John James Audubon State Park — State Park in Kentucky
• Lincoln State Park — State Park in Indiana
• Hoosier National Forest — National Forest in Indiana
• Land Between The Lakes National Forest — National Forest in Kentucky, Tennessee
• Port Royal Covered Bridge — Covered Bridge in Tennessee